My employer provides me with a work vehicle and my wife works two blocks from me. I drop here off and pick her up at the end of the day. We considered a prius awhile back but decided on a subaru as we need a car with some room. All of our shopping is local, 15 mile radius, and some longer trips on the weekend. We drive maybe 8000 miles yearly. Our cars are driven on the weekends and sometimes weeknights. Would the prius have any problems not being driven daily?
The smart key system seems to pull the 12V battery down over time. One option would be to pick up one of these: Battery Tender 021-0123 Battery Tender Junior 12V Battery Charger : Amazon.com : Automotive to plug it into. It comes with an included quick connect that you can wire in for plugging in with little hassle.
If you were driving the Prius on weekends only, it would be fine. If you were driving it once per month, the I'd take css28's advice.
I keep the Prius out of the salt during the Winter. Sometimes it doesn't go out of the garage for 3 or 4 weeks at a time. Have had no problems with the 12V battery, but I am going to pigtail in connectors for a battery tender.