Vehicle: 2007 Toyota Prius (standard trim) Problem The entire audio/entertainment system won’t power on. On the MFD’s Audio screen, I only get an “Audio Off” message. Background & Research I couldn’t find many reports online, but one Reddit thread noted a Prius radio died after the 12 V battery went flat. Someone in the comments fixed it by pulling fuse #17 in the engine compartment, then reinstalling it to power-cycle the system. Initial Troubleshooting Replaced engine-bay fuse #17 (15 A). Radio returned immediately. Next day: audio dead again. Pulled and reinserted fuse #17—radio powered on, but only until the following day. Battery history: the 12 V battery has gone flat multiple times from long periods sitting. Update 1 Replaced three fuses that feed the audio/MFD/clock circuits (all tested good for continuity despite the old blades showing oxidation and heat discoloration): Engine compartment #17 DOME, 15 A Passenger-compartment #17 PANEL, 7.5 A Passenger-compartment #24 ACC, 7.5 A After replacing, I cycled the engine and door locks twice (to mimic leaving and returning)—the radio stayed on. I’ll report back if it still works tomorrow. Related Fuses Engine Compartment 17 DOME 15 A Audio system, interior lights, smart-entry/start, gauges, turn signals, luggage light, clock Passenger Compartment 17 PANEL 7.5 A Multi-information display, clock, audio system, instrument lights Passenger Compartment 24 ACC 7.5 A Audio system, multi-information display, clock Question: Given the symptom returns after a day and the battery has discharged several times, what’s the most likely cause? Similar issues reported here: 1. 2. Radio / CD stopped working | PriusChat