Your AC condenser is in front of your radiator; so it's shielded from road debris. IMHO; proper coolant changes would do more for the health of your cooling system - unless you dumped some sort of sealer into your cooling system. YMMV
First try pulling the bumper cover and spraying the AC condenser and Radiator with cleaner designed for it and use a comb designed to fix any bends on the fins of the condenser and radiator. This will give you an opportunity to search for damage that would justify replacement. In general Gen2 engines don't have an issue with running too hot. If this was a 2010-2015 Prius that has a known problem with cooling system running too hot and engine cooling pumps running too hot/failing that likely contributes to a relatively common head gasket failure, then yes it would be wise. Fortunately Gen2 wasn't designed by idiots trying to fit a bigger engine into a high mpg economy car.
You'll need an AC condenser long before you'll ever be discussing the radiator unless you've clogged it up with stop leak
Pretty sure the cooling system was designed to and functions quite well in both gens. The problems really start when aftermarket replacements are substituted - which applies to most things under the hood. It is particularly foolish if you replace a good oem part with an aftermarket maf, coil, egr valve (gen3 only), water pump(s), radiator, ac condenser or injector. Since the op says "no problems", the smart thing is don't fix it if its not broken. Spend your money where it counts - on fluid replacements. Brake fluid, both cooling systems (50k miles or less), engine (5k miles or less) and transaxle. Filters, engine, cabin, oil filters. Battery blower wheel inspection and clean if needed. Obviously new oem parts are ok if money is not an issue. However there are counterfeit oem parts in fake Toyota packaging on ebay and amazon.
Maybe change your tire valve stem covers instead . Just color choices no thinking. Radiators work really well until you see a puddle of fluid underneath them then is time. Proactiv ride the bike a few times a week .
Combs will not work on the condenser, the pattern is alternating up/down triangles - there is no way to "comb" through it. I did spend a couple of hours cleaning up the condenser at one point, getting all the tiny rocks out of it, straightening the fins. It is amazing how many itty bitty rocks are around that exactly fit into the triangles and wedge there. After using foaming A/C coil cleaner and rinsing with distilled water used a whole lot of round wood toothpicks to clean out rebuild the triangles. The A/C seemed to work much better after that, but then the bottom third or so was in pretty poor shape. The upper 2/3 was mostly OK. I didn't touch the radiator, other then rinsing it out with the distilled water slightly, with however much went straight through the condenser from the front. The back of the radiator is covered by the fans and the front by the condenser. Unless the car is leaking coolant from the radiator, or maybe if it is overheating, I wouldn't touch the radiator. It is a good idea to change the radiator cap occasionally (150k miles?), as in general (many makes and models) the spring can get weak as it ages and coolant can be lost that way.
I've only tried the combs on a rooftop AC on an RV and didn't get very good results so I hear what you're saying.... And yes I wouldn't touch the radiator in a gen2 if it didn't have a problem. However I'm restoring a Gen 3 (2010) that lived under some big trees for several years with dead batteries and because the AC condenser is leaking and no AC and because someone on here who did that replacement job said in hindsight they should of replaced the radiator at the same time that's what I'm going to do because you can get an AC condenser and Radiator for a 2010 for $100 on Ebay or just an AC condenser for $65. I'll also probably replace the electric engine coolant pump, or at least set up a way to get more monitoring data because that's a weak link that could cause headgasket failure. And again none of this relevant to Gen2 Prius.
